RICU肺炎患者主要病原菌分布及耐药性分析

Analysis of Pathogen Distribution and Drug Resistance Isolated from Patients in Respiratory Intensive Care Unit

目的分析郑州市中心医院RICU肺炎患者主要病原菌的分布及耐药情况,为临床医师选择抗菌药物提供参考。方法收集2009年1月—2010年5月郑州市中心医院RICU肺炎患者922份细菌培养及药敏结果,标本来源于来自下呼吸道、血液、胸腔积液,对主要病原菌种类及其耐药性进行回顾性分析。结果共分离出病原菌283株,阳性率30.69%,主要病原菌依次为:铜绿假单胞菌、鲍曼不动杆菌、金黄色葡萄球菌、白色念珠菌、肺炎克雷伯杆菌、乙酸钙不动杆菌、大肠埃希菌。结论 RICU病房患者的病原菌以革兰阴性杆菌为主,耐药率高;金黄色葡萄球菌及白色念珠菌感染率有上升趋势;临床医师应合理用药、减少耐药发生。

Objective To provide the reference for clinicians making proper antimicrobial choice,by analysing the main pathogenic bacteria distribution and drug resistance of patients with pul-monary infection in RICU of the Central Hospital of Zhengzhou city.Methods Collectted 922 quali-fied sputum samples from patients with pulmonary infection in RICU of the Central Hospital of Zheng-zhou city from 2009 to May,2010.Analysed bacteria and antimicrobial susceptibility test results of main pathogens.Results 283 pathogens were isolated,the positive rate is 30.69%.The former spe-cies were： Pseudomonas aeruginosa,Acinetobacter baumanii,Staphylococcus aureus,Candida albi-cans,Klebsiella pneumoniae,Acetic acid calcium acinetobacter,escherichia coli.Conclusion Gram-negative bacterium was the main pathogens of patients with pulmonary infection in RICU ward,with high bacteria resistance.Staphylococcus aureus and Candida albicans infections has increased.Clini-cians should use antimicrobial rationally to reduce resistance occur