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热对成骨和破骨细胞影响及热休克蛋白和因子参与调节的研究进展 被引量：1

Effect of heat in treatment of bone disease and bone regeneration and process of repair
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摘要 热物理因素在骨疾病的治疗、骨再生修复过程中的应用及对成骨细胞影响重要性的认识不断被深化,一定温度热处理可促进成骨细胞分化,热休克蛋白及热休克因子参与细胞保护与分化。但目前尚未阐明热对成骨细胞与破骨细胞偶联关系的影响及热休克蛋白70(HSP70)和热休克因子2(HSF2)对成骨细胞RANKL的调节机制。探明该影响及调节机制可能成为揭示热物理干预影响骨转化的关键所在之一。 How to use physic agent of heat in treatment bone diseases and in repair bone defect and how to be affected the osteoblast by heat have been proved gradually.Invariably heat treatment can promote osteoblast differentiation and the heat shock protein and the heat shock factors participate in cellular protection.The influence of the heat for the relationship of osteoblast and osteoclast and the regulatory mechanism of HSP70 and HSF2 for the RANKL of osteoblast has been not interpreted thoroughly.To find out the influence and the regulatory mechanism can reveal the key point of heat how to interfere in bone transformation.
作者 杨彤涛 甘璐 张小平 孙海滨 韩康 贠哲 周勇
机构地区 第四军医大学唐都医院骨科
出处 《现代生物医学进展》 CAS 2010年第22期4369-4372,共4页 Progress in Modern Biomedicine
基金 陕西省自然科学基金资助(2007C243)
关键词 热 成骨细胞 破骨细胞 热休克蛋白 热休克因子 heat, osteoblast, osteoclast, heat shock protein, heat shock factor
分类号 Q274 [生物学—细胞生物学]
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参考文献21

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二级参考文献16

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现代生物医学进展
2010年 第22期

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