摘要
补肾中药治疗骨关节炎主要通过减轻损伤、延缓退变及促进软骨分化和修复两方面起作用,其机制包括(1)抑制促分解细胞因子的表达;(2)阻止自由基的生成,抑制NOS的活性,减少NO的生成;(3)对关节软骨细胞凋亡的调控;(4)对关节软骨细胞增殖的作用;(5)对关节软骨基质的作用;(6)提高促合成性细胞因子的表达等方面。
Tonifying Kidney Herbs treat of osteoarthritis,mainly by reducing the protection of cartilage damage,delay cartilage degeneration and to promote both differentiation and repair work,the mechanism includes(1) inhibit the expression of cytokines which promoting decomposition;(2) prevent free radicals formation,inhibit the activity of NOS,reducing NO formation;(3) the regulation of apoptosis of articular cartilage;(4) on articular cartilage cell proliferation;(5) the role of the matrix of articular cartilage;(6) increase anabolic cytokine expression,etc.
出处
《中华中医药学刊》
CAS
2010年第12期2515-2518,共4页
Chinese Archives of Traditional Chinese Medicine
基金
高等学校博士学科点专项科研基金(20093237110005)
关键词
中药
关节软骨
保护机制
综述
Traditional Chinese Medicine
Articular Cartilage
Peotect Mechanism