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肿瘤型M2丙酮酸激酶在乳腺癌中表达的意义及其临床应用价值 被引量：3

The expression and value of tumor type M2 pyruvate kinase in the diagnosis of breast cancer
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摘要 目的:探讨肿瘤型M2丙酮酸激酶(TuM2-PK)在乳腺癌患者血中的表达水平及其临床应用价值。方法:用ELISA法分别检测52例乳腺癌、36例乳腺良性病变患者和60名健康体检者血浆中的TuM2-PK表达水平,并进行比较分析。结果:TuM2-PK在乳腺癌组阳性率为76.92%,乳腺良性病变组为16.67%,健康对照组为20.00%,乳腺癌组明显高于后两组(P<0.01),有淋巴结转移患者TuM2-PK阳性率(81.25%)高于无淋巴结转移患者(45.00%)(P<0.05)。结论:TuM2-PK对乳腺癌的辅助诊断有较高的临床价值,并对判断淋巴结转移及临床治疗具有一定的指导意义。 Objective： To investigate the expression and diagnostic values of tumor M2-PK（TuM2-PK） in breast cancer.Methods： The concentration of tumor M2-PK in plasma was detected by ELISA in 52 patients with breast cancer,36 patients with breast benign disease and 60 health controls.Results： TuM2-PK concentration in plasma and the positive rate were singificanfly higher in breast cancer（76.92%） than that in breast benign disease and in health controls（16.67% and 20.00%,respectively）（P〈0.01）,TuM2-PK levels was higher in breast cancer patients with lymph node metastasis（81.25%） than that without metastasis（45.00%）（P〈0.05）.Conclusion： The measurement of TuM2-PK is of great clinical value for the diagnosis of breast cancer,and is helpful in the evaluation of lymph node metastasis.
作者 方伟达 梁文勇 余其昌
机构地区 广东省开平市中心医院肿瘤科
出处 《中国医药导报》 CAS 2010年第35期22-23,共2页 China Medical Herald
关键词 乳腺肿瘤 肿瘤标志物 丙酮酸激酶 Breast neoplasm Tumor marker Pyruvate kinase
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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二级参考文献42

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共引文献37

同被引文献42

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中国医药导报
2010年 第35期

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