三氮唑并噻二嗪类杂环化合物的酰化反应研究

Study on the acylation of s-trizolo thiadiazines hetercyclic compound

目的:合成三氮唑并噻二嗪类杂环化合物并对其进行结构修饰,得到新的三氮唑并噻二嗪类衍生物。方法:以乙酸乙酯为原料通过肼解、缩合等步骤合成甲基取代均三氮唑,再与儿茶酚类经亲核取代、缩合等步骤合成三氮唑并噻二嗪类杂环化合物母核,用醋酐酰化进行结构修饰,修饰结构用质谱进行认证。结果:合成了3-甲基-6(3,4-二羟基苯基)-1,2,4-三氮唑并[3,4-b]噻二嗪及其酰化产物,化合物的分子量通过MSQUEDING。结论:本法简单、方便,为较好的三氮唑并噻二嗪类杂环化合物酰化反应物的合成路线。

Objective： To get new s-trizolo thiadiazine derivative by making sturctral modification on the s-trizolo thiadiazines hetercyclic compound.Methods： With ethyl acetate as starting materials,methyl-s-trizole was synthesized,and then upon reaction with ɑ-haloketon in two steps,1,2,4-trizolo thiadiazine was synthesized,acylated compound was gotten under reaction in refluxed acetic anhydride,the products were identified by MS.Results： 3-methyl-6（3,4-dihydroxylphenyl）-1,2,4-trizolo thiadiazine and its acylated product was synthesized,the molecular weight of them were identified by MS.