唑来膦酸治疗恶性肿瘤骨转移性疼痛62例临床分析

Observation of Zoledronic Acid in the treatment of bone metastasis pain caused by malignant tumors

目的:观察唑来膦酸治疗恶性肿瘤骨转移性疼痛的止痛效果与不良反应。方法:62例恶性肿瘤骨转移性疼痛患者给予唑来膦酸注射液4 mg,用100 ml生理盐水稀释后静脉滴注,每4周1次,连用2次。结果:临床骨转移性止痛效果显示,显效18例,有效32例,无效12例,总有效率为83.33%(50/62)。主要不良反应为恶心、呕吐、发热、转氨酶升高及低血钙,给予对症支持治疗后症状均可逆转。结论:唑来膦酸治疗恶性肿瘤骨转移性疼痛效果明显,不良反应可耐受。

Objective： To investigate the effect and adverse effect of Zoledronic Acid in the treatment of bone metastasis pain of malignant tumors.Methods： 62 patients with bone metastasis pain were treated with 4 mg Zoledronic Acid Injection diluted with 100 ml physiologic saline by intravenous drip infusion per 4 weeks.Two cycles of Zoledronic Acid were used before the response could be evaluated.Results： The effect of pain relieving by Zoledronic Acid showed that,18 cases were excellent,32 cases were effective,12 cases were invalid,and the total effective rate was 83.33%（50/62）.The main adverse effects were upset of digestive tract,fever,high aminopherase and low calcium in blood,all could be removed by giving supportive treatments.Conclusion： The effect of malignant bone metastasis pain treated with Zoledronic Acid Injection is obvious and adverse effects are tolerant.