法舒地尔联合丹红注射液治疗肺动脉高压疗效观察

The therapeutic effect of fasudil hydrochloride and Danhong injection on the pulmonary hypertension

目的观察法舒地尔联合丹红注射液治疗COPD患者肺动脉高压的疗效。方法将110例肺动脉高压患者随机分为2组,治疗组和对照组各55例,对照组接受常规治疗,治疗组在接受常规治疗的同时,给予法舒地尔30 mg、丹红注射液30 ml静脉滴注,每日1次,以14 d为1疗程。治疗前和疗程结束后分别观察平均肺动脉压力(MPAP)、动脉氧饱和度(SaO_2)及动脉氧分压(PaO_2)变化。结果治疗组总有效率为94.5%,高于对照组的72.7%,差异有统计学意义(P<0.05)。2组均可明显改善肺心病患者的临床症状,降低MPAP,升高PaO_2、SaO_2,与治疗前比较有统计学意义(P<0.05),且治疗组优于对照组,差异有统计学意义(P>0.05)。结论法舒地尔联合丹红注射液治疗肺动脉高压疗效确切。

Objective To observe the therapeutic effect of fasudil hydrochloride and Danhong injection on pulmonary arterial hypertension.Methods One hundred and ten pulmonary arterial hypertensive patients were screened and divided into 2 groups：control group（55 cases） and treatment group（55cases）.Control group was general treatment. Treatment group was treated by fasudil hydrochloride injection（30 mg in 5%GLU or NS 150ml） and Danhong injection （30 ml in 5%Glu or normal suline 150 ml）,once a day,beside general treatment for 14 days.Mean pulmonary artery pressure（MPAP）,arterial oxygen saturation（SaO_2） and arterial partial pressure of oxygen（PaO_2） were observed preteatment and after treatment course.Results Total effective rate in the treatment group and the control up was 94.5%and 72.7%,respectively.All clinical symptoms of the heart disease of pneumonic in treatment group was apparendy alleviated and the MPAP decreased,PaO_2,SaO_2 increased obviously compared with those before treatment（P0.05）,which was better in treatment group than control group（P0.05）.Conclusion Fasudil hydrochloride and Danhong injection was effective on the treatment of pulmonary arterial hypertension.