摘要
目的研究p21在翼状胬肉中的表达,探讨其与翼状胬肉临床病理特征的关系。方法采用免疫组织化学S-P法,检测p21在62例翼状胬肉和20例正常结膜中的表达情况,并分析其与翼状胬肉临床病理特征的关系。结果 62例翼状胬肉组织及20例正常结膜中p21的阳性表达率分别为40.3%(25/62)、70.0%(14/20),差异有统计学意义(P<0.05);p21的表达与临床分期、类型关系密切(P<0.05),与其他临床病理指标无关(均P>0.05)。结论 p21在翼状胬肉中呈低表达,其阳性表达率随临床分期、类型进展而降低。
Objective To investigate the correlation between p21 gene expression in pterygium and clinical pathological characteristic,which may provide the theoretical evidence for better treatment of pterygium.Methods Immunohistochemical S-P staining method was used to detect the expression of p21 in 62 cases of pterygia and 20 cases of normal conjunctival tissue.Relationship between expression of p21 and clinical pathological characteristic was analyzed.Results The positive expression rate of p21 in pterygia was 40.3%（25/62） compared to 70.0%（14/ 20）in normal conjunctival tissue（P0.05）.Further analysis indicated that the expression of p21 was correlated with clinical types and stages（P0.05）,there was no relation between expression of p21 and other clinicopathological indexs（P0.05）.Conclusion The expression of p21 was decreased according to clinical type or stage of pterygium.
出处
《疑难病杂志》
CAS
2010年第12期911-912,共2页
Chinese Journal of Difficult and Complicated Cases
