甲状腺激素转运体的研究进展

Advances in thyroid hormone transporters

甲状腺激素在细胞和组织的生长、发育、代谢中发挥了重要的作用.长期以来一直认为亲脂性的甲状腺激素可以直接扩散到细胞内,但越来越多的证据显示甲状腺激素进出细胞是由细胞膜上的转运体介导的,这些甲状腺激素转运体的出现将有助于探讨甲状腺激素的组织特异性调节机制.

Thyroid hormones play important roles in growth, development, and metabolism of various cells and tissues. It has been assumed for a long time that thyroid hormones are lipophilic and enter cells by passive diffusion, but it has become increasingly clear that cellular uptake and efflux of thyroid hormones are mediated by transporters. The discovery of these thyroid hormone transporters will lead to a better understanding of the tissuespecific regulation of thyroid hormones.