侵袭性念珠菌病实验室诊断现状的分析与思考

Analysis and current situation of laboratory diagnosis for invasive candidiasis

侵袭性念珠菌病是第4位医院血源感染性疾病,迄今缺乏理想的诊断方法。尽管以念珠菌抗原、抗体和核酸为靶标的检测方法的研究取得了很大的进展,但由于敏感性、特异性、标准化以及实验设计等原因,难以解决临床实际问题。高度保守、含量丰富的诊断标志物可能是解决这一问题的良好出路。

Ideal diagnostic method of invasive candidiasis,the fourth nosocomial infection are urgently desirable to date.Even though great progress has been made on the subject which uses the antigen,antibody and nucleotide as the detection targets,they are hard to solve the practical problems in terms of clinical requirement due to issues such as sensitivity,specificity,standardization and design of study.Highly conserved and high quantity of diagnostic markers might be a good solution to such problem.