miRNAs与肝细胞癌

miRNAs and hepatocellular carcinoma

最近发现一类小分子物质——microRNAs在肝细胞癌中异常表达,其中部分已被证实与肝细胞癌的发生发展密切有关。有些microRNAs与肝细胞癌的分型有关,提示microRNAs在肝细胞癌的诊断和预后判断中有着潜在的作用;有些microRNAs被证实为肝细胞癌发生的独立危险因素,为临床早期筛查和风险评估提供了分子标记,也为个体化治疗提供了分子依据。

Recently,a new group of molecules,microRNAs,have been discovered to be aberrantly expressed in hepatocellular carcinoma（HCC） and some of them are functionally involved in HCC carcinogenesis and progression.Certain microRNAs are associated with HCC subtypes,implying that microRNAs have a potential value in the diagnosis and prognosis of HCC;some of these HCC-associated microRNAs have been validated in independent cohorts,providing a molecular marker for early screening for clinical and risk assessment,but also providing a molecular basis for individual treatment of HCC.