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变形菌视紫红质十年的回顾与展望 被引量：3

The Review and Prospect of Proteorhodopsin in Ten Years
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摘要 变形菌视紫红质(proteorhodopsin,PR)是一类吸光色素膜蛋白,它是由7个跨膜ɑ-螺旋(A～G)组成的视蛋白(opsins)与色素视黄醛(retinal)通过共价键结合而形成。PR广泛存在于海洋和淡水水域的微生物中,是一种质子泵型的视紫红质,可在光的驱动下将质子从细胞质泵到胞质间隙,从而在细胞内外产生质子梯度,形成的化学势能被用于合成ATP、物质的跨膜运输以及驱动鞭毛运动等方面。据估算含PR的细菌在海洋水域中约占总细菌的13%,而每个含PR的细胞中的PR分子数约为2.5×104个。对PR功能的研究表明PR具有增强其宿主菌抵抗外界不良环境的能力;而对于PR三维结构的研究对PR的作用机理及其功能的研究将有更进一步的推动作用。 Proteorhodopsin（PR） is a seven-transmembrane protein which uses retinal as its chromophore.This protein was found widely distributed in the ocean and some freshwater around world since the first report about it ten years ago.PR is a light driven proton pump which generates proton motive force by translocating protons across the cell inner membrane.Calculation shows that PR-bearing bacterium is one of the numerically richest microorganisms on the Earth,accounting for 13% of the total in sea surface water,and with averaged 2.5×104 PR molecules per cell.Recent studies show that proteorhodopsin phototrophy confers a fitness advantage to marine bacteria during periods of resource deprivation at the ocean＇s surface.
作者 王宁 兰艳黎 王伟武
机构地区 南京农业大学生命科学学院/农业部农业环境微生物工程重点开放实验室
出处 《生物物理学报》 CAS CSCD 北大核心 2010年第11期1036-1046,共11页 Acta Biophysica Sinica
基金 国家自然科学基金(30700135) 教育部回国留学人员启动基金教外司留[2008]890号~~
关键词 变形菌视紫红质 质子泵 光循环 生理功能 Proteorhodopsin Light-driven proton pump Photocycle Physiological function
分类号 Q513.4 [生物学—生物化学]
  • 相关文献

参考文献46

  • 1Wallin E, Heijine G. Genome-wide ananlysis of integral membrane proteins from eubacterial ,archaean,and eukaryotc organisms. Protein Sci, 1998, 7:1029-1038.
  • 2Beja O, Aravind L, Koonin EV, Suzuki MT, Hadd A, Nguyen LP, Jovanovich SB, Gates CM, Feldman IRA, Spudich JL, Spudich EN, DeLong EF. Bacterial rhodopsin evidence for a new type of phototrophy in the sea. Science, 2000, 289:1902-1906.
  • 3Oesterhelt D, Stoeckenius W. Functions of a New Photoreceptor Membrane. Nature New Bio, 1971, 233:149.
  • 4Hoff WD, Jung KH, Spudich JL. Molecular mechanism of photosignaling by archaeal sensory rhodopsins. Annu Rev Biophys Biomol Struct, 1997, 26:223-258.
  • 5Grigorieff N, Ceska TA, Downing KH, Baldwin JM, Henderson R. Electron-crystallographic refinement of the structure of bacteriorhodopsin. J Mol Biol, 1996, 259: 393--421; J Mol Biol, 1996, 259:393.
  • 6Lanyi JK. Understanding structure and function in the light-driven proton pump bacteriorhodopsin. J Struct Biol, 1998, 124:164.
  • 7Spudich JL, Yang CS, Jung KH, Spudich EN. Retinylidene proteins: structures and functions from archaea to humans. Annu Rev Cell Dev Biol, 2000, 16:365-392.
  • 8Torre JR, Christianson LM, Beja O, Suzuki MT, Karl DM, Heidelberg J, DeLong EF. Proteorhodopsin genes are distributed among divergent marine bacterial taxa. Proc NaU Acad Sci USA, 2003, 28; 100:12830-12835.
  • 9Sabehi G, Massana R, Bielawski JP, Rosenberg M, Delong EF, Beja O. Novel Proteorhodopsin variants from the Mediterranean and Red Seas. Environ Microbiol, 2003, 5: 842-849.
  • 10Venter JC, Remington K, Heidelberg JF, Halpern AL, Rusch D, Eisen JA, Wu D, Paulsen I, Nelson KE, Nelson W, Fouts DE, Levy S, Knap AH, Lomas MW, Nealson K, White O, Peterson J, Hoffman J, Parsons R, Baden-Tillson H, Pfannkoch C, Rogers YH, Smith HO. Environmental genome shotgun sequencing of the Sargasso Sea. Science, 2004, 304:66-74.

二级参考文献35

  • 1Fenchel T. Marine bugs and carbon flow. Science, 2001, 292:2444-2445
  • 2Beja O, Koonin E V, Aravind L, et al. Bacterial rhodopsin: Evidence for a new type of phototrophy. Science, 2000, 289:1902- 1906
  • 3Friedrich T, Geibel S, Kalmbach R, et al. Proteorhodopsin is a light-driven proton pump with variable vectoriality. J Mol Biol,2002, 321:821-838
  • 4Sabehi G, Loy A, Jung K-H, et al. New insights into metabolic properties of marine bacteria encoding proteorhodopsins. PLoS Boil, 2005, 3(8): e273
  • 5Spudich J L, Yang C S, Jung K H, et al. Retinylidene proteins:structures and functions from archaea to humans. Annu Rev CellDev Biol, 2000, 16:365-392
  • 6Haupts U, Tittor J, Oesterhelt D. Closing in on bacteriorhodopsin:progress in understanding the molecule. Annu Rev Biophys Biomol Struct, 1999, 28:367-399
  • 7Bogomolni R A, Stoeckenius W, Szundi I, et al. Removal of transducer HtrⅠ allows electrogenic proton translocation by sensory rhodopsin Ⅰ. Proc Natl Acad Sci USA, 1994, 91: 10188-10192
  • 8Bieszke J A, Braun E L, Bean L E, et al. The nop-1 gene of Neurospora crassa encodes a seven transmembrane helix retinalbinding protein homologous to archaeal rhodopsins. Proc Natl Acad Sci USA, 1999, 96:8034-8039
  • 9Sineshchekov O A, Jung K H, Spudich J L. Two rhodopsins mediate phototaxis to low- and high-intensity light in Chlamydomonas reinhardtii. Proc Natl Acad Sci USA, 2002, 99:8689-8694
  • 10Jung K H, Trivedi V D, Spudich J L. Demonstration of a sensory rhodopsin in eubacteria. Mol Microbiol, 2003, 47:1513-1522

共引文献2

同被引文献46

  • 1Van der Horst M A, Hellingwerf K J. Photoreceptor proteins, "star actors of modem times": a review of the functional dynamics in the structure of representative members of six different photoreceptorfamilies[J]. Acc Chem Res, 2004, 37: 13-20.
  • 2Moglich A, Yang X, Ayers R A, et al. Structure and function of plant photoreceptors. Annu[J]. Rev. Plant Biol, 2010, 61: 21-47.
  • 3Demarsy E, Fankhauser C. Higher plants use LOV to perceive blue light[J]. Curr Opin Plant Biol, 2009, 12: 69-74.
  • 4Ren Z, Perman B, Srajer V, et al. A molecular movie at 1.8 A resolution displays the photocycle of photoactive yellow protein, a eubacterial blue-light receptor, from nanoseconds to seconds[J]. Biochemistry, 2001, 40: 13788-13801.
  • 5Dasgupta J, Frontiera R R, Taylor K C, et al. Uhrafast excited- state isomerization in phytochrome revealed by femtosecond stimulated Raman spectroscopy [J]. Proc Natl Acad Sci USA, 2009, 106: 1784-1789.
  • 6Ulijasz A, Cornilescu G, Cornilescu G C, et al. Structural basis for the photoconversion of a phytochrome to the activated Pfr form [J]. Nature, 2010, 463: 250-254.
  • 7Gauden M, van Stokkum I H, Key J M, et al. Hydrogen-bond switching through a radical pair mechanism in a flavin-binding photoreceptor [J]. Proc Natl Acad Sci USA, 2006, 103: 10895- 10900.
  • 8Barends T R, Hartmann E, Griese J J, et al. Structure and mechanism of a bacterial light regulated cyclic nucleotide phosphodiesterase[J]. Nature, 2009, 459:1015-1018.
  • 9M'" uller M, Carell T. Structural biology of DNA photolyases and cryptochromes[J]. Curr Opin Struct Biol, 2009, 19: 277-285.
  • 10Lamia K A, Papp S J, Yu R T, et al. Cryptochromes mediate rhythmic repression of the glucocorticoid receptor [J]. Nature, 2011,480: 552-556.

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二级引证文献8

生物物理学报
2010年 第11期

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