两种指征的卵胞浆内单精子注射结局的比较

Comparison of Intracytoplasmic Sperm Injection Outcome between Two Indications

目的:探讨常规IVF受精失败患者再次周期行ICSI-ET治疗时,卵子因素对胚胎结局的影响。方法:回顾分析因前次IVF-ET中受精障碍或受精率≤30%而行ICSI治疗的38个周期(A组)和因严重精液异常而行ICSI治疗的181个周期(B组)的ICSI结局。结果:A、B组的受精率(FR)、卵裂率(CR)、胚胎利用率(URE)、胚胎着床率(EIR)、临床妊娠率(CPR)和早期流产率(EAR)分别为82.5%vs78.0%(P<0.05),97.5%vs97.6%(P>0.05),76.4%vs73.1%(P>0.05),10.0%vs19.8%(P<0.05),27.0%vs31.8%(P>0.05),40.0%和16.1%(P>0.05)。结论:常规IVF-ET受精失败的患者,再次周期行ICSI-ET治疗,受精率提高,由于卵子异常对胚胎发育的不利影响,部分胚胎着床和着床后的远期发育潜能降低。

Objective： To analyze the effect of oocytes on embryonic outcomes in patients ICSI-ET cycles who got fertilization failure in their former routine IVF-ET cycles.Methods： A retrospective study was carried out.Intracytoplasmic sperm injection （ICSI） was performed in 38 cases with low fertilization rates （？？0%） or fertilization failure in their former routine IVF-ET cycles （group A） and 181 cases with severely seminal abnormities （group B） treated with ICSI,and their fertilization rates （FR）,cleavage rates （CR）,utility rates of embryos （URE）,embryo implantation rates （EIR）,clinical pregnancy rates （CPR） and early abortion rates （EAR） were compared.Results： The FR,CR,URE,EIR,CPR and EAR of groups A and B were 82.5% vs 78.0% （P0.05）,97.5% vs 97.6%（P0.05）,76.4% vs 73.1%（P0.05）,10.0% vs 19.8% （P0.05）,27.0% vs 31.8%（P0.05）,40.0% vs 16.1%（P0.05）,respectively.Conclusion： FR were raised in patients ICSI-ET cycles who got fertilization failure in routine IVF-ET cycles.Due to abnormal oocytes negative effect on embryonic development,parts of their embyos potency of implantation and long-term development dropped.