胰岛素泵强化治疗120例初发2型糖尿病的疗效观察

Therapeutic effect of insulin pump on newly-diagnosed type 2 diabetes in 119 cases

目的探讨胰岛素泵短期强化治疗初发2型糖尿病患者控制血糖的疗效。方法将初发2型糖尿病患者254例随机分为胰岛素泵持续皮下胰岛素输注治疗组(CSII组)及多次皮下注射胰岛素组(MSII组),2周为1个疗程。CSII组给予胰岛素泵24 h持续治疗,胰岛素剂型为诺和灵R;MSII组采用每日三餐前30 min皮下注射诺和灵R,睡前皮下注射诺和灵N;比较两组治疗前后血糖控制水平、达标时间、胰岛素总量及低血糖反应发生率。结果两组血糖及低血糖发生率均明显降低,但CSII组血糖达标所需时间短于MSII组,胰岛素用量也低于MSII组。结论对初发2型糖尿患者应用胰岛素泵短期强化治疗可快速控制并稳定血糖,是治疗糖尿病强化治疗最有效的方法。

Objective To explore the therapeutic effect of insulin pump on the treatment of newly-diagnosed type 2 diabetes. Methods Totally 254 newly-diagnosed type 2 diabetics were randomly divided into two groups ： continuous subcutaneous insulin infusion by pump group （CSII） and multiple subcutaneous insulin injection group （MSII）. Humulin R was infused to patients in CSII group by insulin pump consistently for 24 hours. MSII group was treated by the subcutaneous injection of Humulin R 30 minutes before daily breakfast and Humulin N be- fore sleep. The blood glucose control level, treating time, insulin dosage and the hypoglycemic incidence between the two groups were compared. Results The blood glucose and hypoglycemic incidence were obviously decreased in both groups, however less treating time and insulin dosage were required in CSII group than those in MSII group. Conclusion Insulin pump intensive therapy in short period can quickly re-control the blood glucose; therefore it is effective for newly-diagnosed type 2 diabetes.