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内脂素基因启动子多态性与中国人2型糖尿病脂代谢紊乱的相关性 被引量：6

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摘要 目的探讨内脂素基因启动子-1535C/T多态性的分布及其与中国人2型糖尿病(T2DM)脂代谢紊乱的关系。方法采用聚合酶链反应-限制性片段长度多态性技术,检测208例初诊T2DM患者和162例糖耐量正常(NGT)者的内脂素基因启动子-1535C/T多态性,分析该基因多态性与腰围、BMI、血浆内脂素及血脂代谢指标的相关性。结果 两组内脂素基因型分布及等位基因频率比较无统计学差异(P>0.05);但与TC、CC基因型患者比较,T2DM组TT基因型患者甘油三酯升高、HDL-C降低(P<0.05)。荧光素酶活性比较,pGL3-1535T的相对荧光素酶表达活性较pGL3-1535C下降了约28%(P<0.01)。结论内脂素基因启动子-1535C/T多态性与中国人T2DM脂代谢紊乱有相关性。
作者 俞力 施良 戴莉敏 孙湘 范钰
机构地区 江苏大学附属医院 江苏大学附属人民医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第22期3250-3252,共3页 Chinese Journal of Gerontology
基金 镇江市分子内分泌重点实验室项目(SS2009012) 教育部出国留学人员科研启动基金(教外司留2006-331号)
关键词 内脂素 多态性 2型糖尿病 血脂异常
分类号 R587.1 [医药卫生—内分泌]
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参考文献7

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二级参考文献12

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共引文献15

同被引文献51

  • 1潘丽莉,张俊,魏江,施媛萍,冯悦华,于洋,罗光华.颈动脉粥样硬化患者MT2A-838G/C和MCP-1-2518G/A基因多态性分析[J].江苏大学学报（医学版）,2013,23(6):501-504. 被引量：1
  • 2James D Falvey,Robert W Bentley,Tony R Merriman,Mark B Hampton,Murray L Barclay,Richard B Gearry,Rebecca L Roberts.Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis[J].World Journal of Gastroenterology,2013,19(39):6656-6664. 被引量：9
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引证文献6

二级引证文献10

中国老年学杂志
2010年 第22期

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