糖皮质激素在骶管注射疗法中的配伍稳定性

Stability of compatibility of glucocorticoid used in sacral injection

目的考察糖皮质激素在骶管注射疗法中常用配伍的稳定性。方法参照骶管注射疗法中常用的药物配伍组方,把研究对象按照糖皮质激素的不同剂量、不同剂型及中西医药物配伍分为7个小组,在室温下分别配制各组药液后,测定在0 min、30 min、1.0 h、2.0 h、4.0 h时各组的外观、pH值及紫外吸收度变化,并采用高效液相色谱法测定各组配伍液中糖皮质激素的变化。结果除大剂量曲安奈德组出现较多肉眼可见的白色沉淀及中西医药物配伍组出现肉眼可见的大量棕色沉淀物外,其余各组别在4h内,其注射液的外观、pH值、紫外吸收度及高效色谱图均无显著性改变;但在配伍24h后可见曲安奈德注射液出现少量分解。结论在骶管注射疗法的药物配伍中,随糖皮质激素混悬液的剂量增加其药物配伍稳定性下降,不论是何种剂型的糖皮质激素均不宜与中药制剂配伍,糖皮质激素混悬液最好现配现用。

Objective To study the stability of compatibility of glucocorticoid used in sacral injection.Methods Reference to commonly used drugs recipes in sacral injection The glucocorticoid used in sacral injection is divided into 7 groups according to the different doses of corticos-teroids,different dosage forms and the compatibility of Chinese and Western medicines.Compound medicines of each group was observed the changes in appearance,pH value and UV absorbance at 0min、30min、1.0h、2.0h、4.0h at the ambient temperature respectively,and then glucocorticoid con-tents were determined by HPLC—UV.Results No significant changes were noted for the mixture within 4h in appearance,pH value,UV absorbance and high performance liquid chromatogram（HPLC）,but triamcinolone can be seen after 24h in the compatibility of a small amount of decomposition occurs;Except Large number of visible white or brown precipitate was appeared in large dose of triamcinolone group and Chinese-Western medicine combined group.Conclusion For the glucocorticoid used in sacral injection,the more simple in compatibility,the more stable;Traditional Chinese medicine and glucocorticoid should not be mixed use,whether agent or suspension.We should strictly follow the principle of using with the current in sacral injection therapy.