吸烟对牙周炎病人血浆内皮素和一氧化氮水平的影响

Effect of smoking on plasma endothelin and nitric oxide levels in periodontitis patients

目的:通过观察吸烟对牙周炎病人血浆内皮素及一氧化氮水平的影响,探讨牙周炎发病的可能相关因素。方法:选择滨州医学院附属医院口腔内科诊断为慢性牙周炎的病人60例,另选无牙周病或黏膜病的牙周健康者35例作为对照;每组又分为吸烟组和不吸烟组。各组在牙周基础治疗前、治疗后4周,分别测定血浆内皮素和一氧化氮水平以、牙周各临床指标。结果:慢性牙周炎组血浆ET、NO水平显著高于对照组(P<0.05),经牙周基础治疗后ET、NO水平均有明显下降,与治疗前相比差异具有统计学意义(P<0.05)。牙周基础治疗前后牙周临床指标的变化表明:吸烟者治疗前后的变化显著小于不吸烟者,差异具有统计学意义(P<0.05),实验组、对照组吸烟者血浆ET和NO水平均显著高于不吸烟者(P<0.05)。结论:慢性牙周炎病人血浆内皮素和一氧化氮水平显著高于对照组,且吸烟者显著高于不吸烟者;吸烟可以显著影响牙周炎的治疗效果。

AIM：To investigate the effects of smoking on plasma endothelin （ ET） and nitric oxide （ NO） levels,and to explore the possible correlative factors of periodontitis. METHODS：Sixty chronic periodontitis patients and 35 periodontally healthy subjects were included in this study. Each group was further divided into smoking and non-smoking group. Periodontal parameters such as probing depth （ PD） ,attachment loss （ AL） and bleeding on probing （ BOP） were measured and plasma ET and NO levels were determined. Plasma ET and NO levels of periodontitis patients were examined before and 4 weeks after the initial therapy. RESULTS：Plasma ET and NO levels of periodontitis patients were significantly higher than those of the healthy subjects （ P 〈 0. 05）. Furthermore,plasma ET and NO levels in smoking group were significantly higher than those in non-smoking group （ P 〈 0. 05）. After initial therapy,plasma ET and NO levels were significantly decreased both in non-smoking and smoking group （ P 〈 0. 01）. At 4 weeks after initial therapy,PD,AL and BOP showed a more significant decrease in non-smoking group than in smoking group （ P 〈 0. 05）. CONCLUSION：Smoking can significantly affect the plasma ET and NO levels,and it may be an important risk factor of chronic periodontitis.