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D-氨基酸氧化酶研究进展 被引量：5

D-amino Acid Oxidase:Update and Review
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摘要 D-氨基酸氧化酶(D-amino acid oxidase:oxidoreductase,DAAO,EC1.4.3.3)是一种以黄素腺嘌呤(FAD)为辅基的典型黄素蛋白酶类,可氧化D-氨基酸的氨基生成相应的酮酸和氨。在体内D-氨基酸的代谢中起着重要作用。主要介绍了D-氨基酸氧化酶的生理功能和应用、表达条件优化及通过定点突变对酶学性质的研究。 D-amino acid oxidase（EC 1.4.3.3,DAAO）is a FAD-dependent enzyme that plays an important role in metabolism of endogenous D-amino acids in living cells.The D-amino acid oxidase（DAAO）catalyzes oxidative deamination of D-amino acids yielding hydrogen peroxide,ammonium and the corresponding α-keto acids.The recent data about this enzyme was summarized,including its physiological role and practical applications,optimization of expression,and the characteristics of some single-point mutant enzyme which designed by a rational approach.
作者 郭姣洁 薛永常 徐书景 张彩凤 何广正 鞠建松
机构地区 大连工业大学生物工程学院 河北师范大学生命科学学院新药研发中心
出处 《中国生物工程杂志》 CAS CSCD 北大核心 2010年第11期106-111,共6页 China Biotechnology
基金 国家自然科学基金(30970628) 河北省留学回国人员资助项目(2010) 河北师范大学博士启动基金(L2009B13)资助项目
关键词 D-氨基酸氧化酶 生理功能 应用 表达 定点突变 D-amino acid oxidase Physiological role Practical application Expression Site-directed mutagenesis
分类号 Q814 [生物学—生物工程]
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参考文献28

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二级参考文献22

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共引文献1

同被引文献79

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引证文献5

二级引证文献16

中国生物工程杂志
2010年 第11期

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