人群血清高敏C反应蛋白水平及其影响因素

The distribution and influential factors of serum high sensitivity C-reactive protein in general population

目的 探讨人群血清高敏C反应蛋白（hs-CRP）水平的分布及其影响因素.方法 于2006-2007年对开滦集团公司101 510名员工进行健康体检,数据完整并纳入分析者91 123例（男性72 805例,女性18 318例）.根据血压、血脂将人群分为健康组和非健康组.结果 （1）研究总人群、男性、女性血清hs-CRP水平几何均数分别为0.70 mg/L、0.70 mg/L、0.73 mg/L,第95百分位数分别为6.28 mg/L、6.20 mg/L、6.49 mg/L.hs-CRP水平随年龄增加而升高（P＜0.001）.健康组与非健康组血清hs-CRP水平几何均数分别为0.54 mg/L（第95百分位数是5.40 mg/L）、0.80 mg/L（第95百分位数是6.57 mg/L）.（2）多重线性回归分析表明,性别、年龄、收缩压、BMI、TC、TG、空腹血糖以及吸烟、冠心病和卒中病史与hs-CRP水平均呈正相关,舒张压、HDL-C、饮酒史与hs-CRP水平呈负相关.结论 国人血清hs-CRP水平随年龄增加而升高;女性hs-CRP水平高于男性;hs-CRP水平受多种传统心血管因素影响.

Objective To observe the distribution and influence factors of serum high sensitivity C-reactive protein （hs-CRP） in general population. Methods In a cross-sectional population survey, a total of 101 510 subjects who were employed by Kailuan Group had been carried out a healthy examination in the period of 2006 to 2007. In the statistical analysis, we observed 91 123 subjects （males 72 805, females 18 318） who had full information and met the inclusion criteria of the study. Results （ 1 ） The geometric means of hs-CRP were 0. 70 mg/L, 0. 70 mg/L and 0. 73 mg/L in all subjects, males and females,respectively, the 95th percentiles were 6.28 mg/L, 6.20 mg/L and 6.49 mg/L, respectively. The concentrations of hs-CRP increased with age in both males and females （P trend = 0. 001 ）. Serum hs-CRP geometric mean was 0. 54 mg/L and the 95th percentile was 5.40 mg/L in health group, while the geometric mean was 0. 80 mg/L and the 95th percentile was 6. 57 mg/L in non-health group. （2） Multiple linear regression analysis showed that concentrations of hs-CRP were positively associated with gender, age,systolic blood pressure, body mass index, total cholesterol, triglycerides, fasting blood glucose, smoking history, history of coronary heart disease and stroke history, but concentrations of hs-CRP were inversely related with diastolic blood pressure, high-density lipoprotein cholesterol and alcohol history. Conclusion Serum concentrations of hs-CRP level increased with age, concentrations of hs-CRP were higher in females than males; a variety of cardiovascular factors effected the concentrations of hs-CRP.