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微小RNA在肾脏及其相关疾病中的调控作用

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摘要 微小RNA（miRNA）是细胞内源性的一种非编码的RNA,可表达出原始miRNA转录物（pri-miRNA）,较大的primiRNA经一种RNA内切酶Ⅲ（Drosha）和辅助因子Pasha（含有双链RNA结合区域）加工成单链miRNA前体,随后具有发卡结构的单链miRNA前体在细胞质中被双链RNA专一性RNA内切酶（Dicer）切割成约22 nt的miRNA.成熟的miRNA中的一条单链与RNA诱导的沉默复合体（RNAinduced silencingcomplex,RISC）结合,形成RISC复合体.通过与靶基因mRNA的3＇非翻译区（3＇UTR区域）的碱基完全或不完全配对,导致mRNA降解或mRNA翻译抑制,即转录后基因沉默[1].
作者 朱楠 袁伟杰
机构地区 上海交通大学附属第一人民医院肾内科
出处 《中华医学杂志》 CAS CSCD 北大核心 2010年第44期3166-3168,共3页 National Medical Journal of China
关键词 微小RNA 调控作用 相关疾病 miRNA 基因MRNA 转录后基因沉默 双链RNA 肾脏
分类号 R686 [医药卫生—骨科学]
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参考文献22

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二级参考文献14

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中华医学杂志
2010年 第44期

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