α-吡唑基-N-苯基-α-氨基膦酸酯的合成及生物活性的初步研究

Synthesis and Preliminary Bio activity Studies of α Pyrazyl N phenyl α aminophosphonates

α－氨基膦酸及其酯与α－氨基酸结构类似，其具有抑菌［１］、抗肿瘤［２］、杀虫［３］以及抗植物病毒［４～７］的活性．α－氨基膦酸酯上与磷原子相连的２个烷氧基不同、α位碳原子以及氨基上取代基的不同将导致生物活性的巨大差异［８］．吡唑是一具有多种生物活性的...

A series of α pyrazyl N phenyl α aminophosphonates was synthesized by the reaction of phosphites with Schiff bases prepared through condensation of substituted anilines with 5 chloro 1 benzyl 3 methyl 4 pyrazylaldehyde. The reaction can be easily carried out without solvent. The two alkoxyl groups linking to phosphorus atom show unequivalent behavior in 1H NMR . The structures of compounds were confirmed by IR, 1H NMR and elemental analysis. The preliminary bioassay shows that some of them possess good fungicide and anti virus activities on some plants.