聚β-羟基丁酸戊酸酯(PHBV)为载体的药物缓释微球的制备

Preparation of Micro-spheres Using PHBV as Carrier for Drug Slowly Releasing

对用ＰＨＢＶ为载体，采用乳化溶剂蒸发法制备黄体酮的缓释微球进行了研究。结果表明，当选用明胶为乳化剂时，可以制得分散、较圆且表面光滑的微球;;明胶浓度及搅拌转速不但影响微球的粒径而且影响药物包埋率;;药物的包埋率还受ＰＨＳＶ在氯仿相中浓度、药物加入量以及制备温度的影响。研究微球体外释放行为发现，当ＰＨＢＶ在氯仿中浓度为０．１（ｗ／ｖ）、黄体酮加入量为ＰＨＢＶ质量的０．０６（ｗ／ｖ）、温度为４０℃时，制得的微球具有较好的缓释效果。

PHBV was used as a carrier for slowly releasing of progesterone. The emulsion solventevaporation method was applied to prepare PHBV micro-spheres containing progesterone. With gelatinas the emulsifier, the discrete and spherical micro-particles with smooth surface were obtained. It wasobserved that both the concentration of gelatin and the stirring rate took an important role for eitherparticle size or encapsulation efficiency. The encapsulation efficiency of progesterone was alsodependent upon the concentration of PHBV in chloroform, the ratio of progesterone to PHBV and thetemperature of preparation. The experimental results of drug release in vitro indicated that theappropriate preparation conditions were : 0. 1(w/v) of PHBV in chloroform, progesterone to PHBV ratioof 0.06:1 (w/w) and temperature at 40℃.