摘要
探讨内脂素(visfatin)与自身免疫性甲状腺疾病的关系,进而为自身免疫性甲状腺疾病的诊断、治疗与预后提供新的思路。采用ELISA法测定不同组别自身免疫性甲状腺疾病患者和健康人群血浆visfatin水平,并分析visfatin与FT3、FT4、TSH、TPO-Ab、TG-Ab、体重指数(BMI)和腰臀比的关系。结果显示,自身免疫性甲状腺疾病患者血浆visfatin水平明显高于对照组(P<0.05);桥本甲状腺炎甲减组血浆visfatin水平高于桥本甲状腺炎甲亢组和Graves病组(P<0.05);桥本甲状腺炎甲亢组血浆visfatin水平高于Graves病组(P<0.05);相关分析显示,Visfatin与FT3、FT4、TSH、TPO-Ab、TG-Ab、BMI和腰臀比不相关(P>0.05)。结论:Visfatin可能参与了自身免疫性甲状腺疾病的发生发展;Visfatin可能做为诊断自身免疫性甲状腺疾病的参考指标。
To investigate the relationship between plasma visfatin levels and autoimmune thyroid disease,the plasma visfatin levels were assayed by ELISA in patients with autoimmune thyroid diseases（AITD） and controls.The relationships of plasma visfatin levels and FT3,FT4,TSH,TPO-Ab,TG-Ab and BMI were analyzed.The results showed that the visfatin levels in patients with AITD were significantly higher than those in controls（P0.05）;and the serum visfatin levels in patients of hashimoto＇s disease with hypothyroidism were significantly higher than those in Hashimoto＇s disease with hyperthyroidism and Graves disease（P0.05）.The plasma visfatin levels in patients of Hashimoto＇s disease with hyperthyroidism were higher than that of in Graves＇s patients.There were no correlations between the plasma levels of FT3,FT4,TSH,TPO-Ab,TG-Ab and visfatin（P0.05）.The visfatin may take part in the AITD pathogenesis and might play an important role in the immuno-pathogenesis of AITD,and may act as reference indexes in the diagnosis of AITD.
出处
《标记免疫分析与临床》
CAS
2010年第6期355-358,共4页
Labeled Immunoassays and Clinical Medicine
基金
黑龙江省卫生厅资助课题(编号:2007-186)
