稳消颗粒对兔实验性动脉粥样硬化血清FIB和CRP表达的影响

Effect of Wenxiao Granule on Expression of FIB and CRP in Rabbit with Atherosclerosis

目的观察稳消颗粒对兔实验性动脉粥样硬化血清C反应蛋白(CRP)和纤维蛋白原(FIB)表达的影响。方法健康新西兰大白兔36只,随机分为空白组(正常饮食)9只和造模组(高脂饮食)27只。造模成功后将造模组再随机分为稳消颗粒组、辛伐他汀组、模型对照组。停用高脂饲料改用标准饲料并根据体重比折算临床剂量给予相应的药物治疗8周。分别于实验前与实验后经耳缘静脉采血,检测CRP和FIB水平。结果与空白组相比,稳消颗粒组、辛伐他汀组和模型对照组的CRP、FIB水平显著增高(P<0.05);稳消颗粒组、辛伐他汀组CRP、FIB明显低于模型对照组(P<0.05),但稳消颗粒组、辛伐他汀组之间比较无统计学意义(P>0.05)。结论稳消颗粒可降低CRP、FIB水平,有利于AS斑块稳定。

Objective To observe the effect of Wenxiao granule on blood serum C-reactive protein（CRP）and fibrinogen（FIB） in the aortic roots of rabbit with atherosclerosis（AS）.Methods Thirty-six New Zealand rabbits were fed a high-fat diet for 8 weeks until the mature atherosclerotic plaques were formed,then they were randomized to three groups：Model control group,Wenxiao granule group,simvastatin group.The rabbits in two drug-treated groups were treated with respective drug and fed the standard food for another 8 weeks.At the end of experiment,all rabbits were sacrificed and blood was collected to test the concentration of CRP and FIB.Results Compared with the blank control group,the concentration of CRP and FIB were increased in Wenxiao granule group,simvastatin group and model control group（P0.05）.The concentration of CRP and FIB in Wenxiao granule group and simvastatin group was significantly lower than that in atherosclerosis model group（P0.05）,but there was no significant difference between Wenxiao granule group and simvastatin group（P0.05）.Conclusion Wenxiao granule could inhibit the level of CRP and FIB,which might stabilize plaque of AS.