抗生素相关性腹泻危险因素的多元回归分析

Multiple Regression Analysis of Risk Factors of Antibiotic-associated Diarrhea

目的:分析抗生素相关性腹泻引起的危险因素。方法:采用回顾性与Logistic回归分析法,筛选出导致相关性腹泻的危险因素。将应用抗生素的1220例患者的临床资料分为无抗生素相关性腹泻患者(对照组),发生抗生素相关性腹泻患者(观察组),比较两组患者的个体情况,抗生素应用情况,治疗过程的差异,并进行单因素与Logistic回归分析。结果:1220例患者中发生抗生素相关性腹泻5.74%(70/1220),经单因素检验10种变量指标是引起抗生素相关性腹泻的危险因素(P<0.05),与患者性别,抗生素应用指征,给药途径无关(P>0.05);Logistic回归分析,并按OR值的大小排序,患者引起抗生素相关性腹泻的危险因素依次为高年龄,长时间应用抗生素、多种类抗生素,侵袭性医疗操作,禁食与重病症。结论:抗生素相关性腹泻发生率高与多种因素有关,应加强对高龄患者的用药监测,合理使用抗生素,并减少或避免侵袭性医疗操作。

Objective：To analyze the risk factors caused by antibiotic-associated diarhea.Methods：Using logistic regression analysis by retrospection,the risk factors of antibiotic-associated diarhea have been screened.The clinical data of 1 220 patients using antibiotics were divided into no antibiotic-associated diarhea patients（control group） and antibiotic-associated diarhea cases（observation group）.Two groups of individuals,antibiotics use,treatment process were compared by single factor and logistic regression analysis.Results：The antibiotic-associated diarhea patients were 5.74%（70/1 220） in 1 220 cases.By the single factor,10 kinds of variable index were a cause of antibiotic-associated diarhea risk factors（P0.05）,and the patients sex,antibiotics indications and method of administration were irrelavant（P0.05）.By logistic regression analysis and sort by size of OR,the risk factors of antibiotic-associated diarhea patients were elder age,antibiotics using a long time,many kinds of antibiotics,invasive medical operation,fasting and heavy disease respectively.Conclusion：The high incidence rate of antibiotic-associated diarhea were related to many factors and the monitoring of the drug,reasonable use of antibiotics and reducing or avoiding invasive medical operation should be strengthened.