期刊文献+

脑肠肽、摄食调控与肥胖关系的研究进展 被引量:7

下载PDF
导出
摘要 单纯性肥胖的发生是能量代谢失衡的表现。脑肠肽包括促食欲肽和抑食欲肽,与摄食中枢的调节及能量摄入密切相关。Ghrelin是目前唯一可知的外周促食欲素,可以增加食欲,促进摄食。而另一些脑肠肽如胰多肽(PP)、肽YY(PYY)、胰高血糖素样肽-1(GLP-1)、胃泌酸调节素(OXM)的作用主要为抑制摄食。两类激素通过食欲调节中枢相互作用,对肥胖的发生发展产生重要的影响。研究并阐明脑肠肽激素在胃肠道中的分布、代谢与食欲调控机制,有可能成为未来肥胖预防和治疗的靶标。
出处 《国际消化病杂志》 CAS 2010年第6期357-360,共4页 International Journal of Digestive Diseases
  • 相关文献

参考文献27

  • 1Baldanzi G,Filigheddu N,Cutrupi S,et al.Ghrelin and desacyl Ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.J Cell Biol,2002,159:1029-1037.
  • 2Tschop M,Smiley DL,Heiman ML.Ghrelin induces adiposity in rodents.Nature,2000,407:908-913.
  • 3English PJ,Ghatei MA,Malik IA,et al.Food fails to suppress Ghrelin levels in obese humans.J Clin Endocrinol Metab,2002,87:2984.
  • 4Murray CD,Le RC,Gouveia C,et al.The effect of different macronutrient infusions on appetite,Ghrelin and peptide YY in parenterally fed patients.Clin Nutr,2006,25:626-633.
  • 5Williams DL,Grill HJ,Cummings DE,et al.Vagotomy dissociates short-and long-term controls of circulating Ghrelin.Endocrinology,2003,144:5184-5187.
  • 6Cowley MA,Smith RG,Diano S,et al.The distribution and mechanism of action of Ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.Neuron,2003,37:649-661.
  • 7Theander-Carrillo C,Wiedmer P,Cettour-Rose P,et al.Ghrelin action in the brain controls adipocyte metabolism.J Clin Invest,2066,116:1983-1993.
  • 8Sun Y,Ahmed S,Smith RG.Deletion of Ghrelin impairs neither growth nor appetite.Mol Cell Biol,2003,23:7973-7981.
  • 9Batterham RL,Cohen MA,Ellis SM,et al.Inhibition of food intake in obese subjects by peptide YY3-36.N Engl J Med,2003,349:941-948.
  • 10Mittelman SD,Klier K,Braun S,et al.Obese adolescents show impaired meal responses of the appetite-regulating hormones Ghrelin and PYY.Obesity (Silver Spring),2010,18:918-925.

同被引文献59

引证文献7

二级引证文献32

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部