摘要
目的探讨碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)及成纤维细胞生长因子受体-2(fibroblast growth factor receptor-2,FGFR-2)在胃癌组织中的表达及其意义。方法应用免疫组化SP法检测100例胃癌及癌旁组织,bFGF和FGFR-2的表达及两者之间的关系。结果胃癌中bFGF和FGFR-2表达明显高于癌旁组织及正常组织(P<0.01),胃癌组织中bFGF、FGFR-2表达的水平与临床病理分期有关,中晚期胃癌bFGF及FGFR-2阳性率明显高于早期胃癌(P<0.05),胃癌组织中bFGF与FGFR-2表达呈正相关,随bFGF表达的增高FGFR-2表达亦增高(P<0.05)。结论 bFGF和FGFR-2在胃癌组织中表达明显增高可能与肿瘤的发生发展有关。
Objective To investigate the expression, location and respective Significance of basic fibroblast growth factor （bFGF） and fibroblast growth factor receptor - 2 （ FGFR - 2 ） in human gastric careinomal. Methods The expressions of bFGF and FGFR -2 in 100 gastric cancer tissues samples and normal tissues adjacent to the tumor samples and the relationship between the expression of bFGF and FGFR - 2 were detected by using immunohistoehemical method. Results The bFGF and FGFR - 2 were up - regulated in cancer compared with normal tissues. The expression level of bFGF and FGFR -2 in gastric cancer tissues were significantly higher than in adjacent tissues and normal tissues （P 〈0.01 ）. The expression level and clinical pathological staging of the mid - late gastric bFGF and FGFR - 2 positive was significantly higher than early gastric cancer （ P 〈 0. 05 ）. The positive relationship was found between bFGFand FGFR - 2 expression in gastric carcinoma（ P 〈 0.05 ）. Conclusion The over - expressions of bFGF and FGFR - 2 appear in the gastric carcinoma tissues and might be involved in the invasiveness and metastasis of gastric carcinoma.
出处
《中国医学创新》
CAS
2010年第35期1-3,共3页
Medical Innovation of China
