摘要
目的观察小剂量顺铂联合5-氟脲嘧啶持续静脉滴注(L-FP)治疗老年晚期胃癌患者的疗效。方法对33例老年晚期胃癌患者给予氟脲嘧啶(5-FU)250mg/d,持续静脉滴注24h,连续给药2周,顺铂(DDP)10mg/d,静脉滴注1h,每周第1～5d,连续2周,休息1周,3周为一周期。化疗2个疗程后评价疗效及不良反应。结果总有效率51.52%。主要毒副反应为轻度胃肠道反应和骨髓抑制。结论治疗老年晚期胃癌,小剂量顺铂联合5-氟脲嘧啶持续静滴方案是有效、经济和安全的。
Objective To evaluate the efficacy and toxieity of the combination of low - close of CDDP and protracted venous infusion of Fluorouracil（ L - FP） in the treatment of esnile patients with advanced gastric cancer. Methods Thirty - three esnile patients with advanced gastric cancer were treated with L - FP （ CDDP l0 mg/d, dl - 5/w and PVI 5 - fu 250 mg/d ,2 weeks） , the evaluation of efficacy and toxicity were performed on all palients after 2 cycles. Results The tumor response rate observed in this study was 51.52%. The most common adverse effects were gastrointestinal response and myelo- suppression, but could be endured. There were no toxic death. Conclusion The L - FP is a safe and effective regimen for esnile patients with advanced gastric cancer.
出处
《中国医学创新》
CAS
2010年第35期71-72,共2页
Medical Innovation of China
