临产孕妇红细胞参数及凝血四项的检测与分析

An analysis of detection results of RBC parameters and blood coagulation 4 indices of parturient women

目的 了解临产孕妇的红细胞参数与凝血四项的生理变化及意义.方法 采用MindrayBC-3000Plus血细胞分析仪及Sysmex CA500全自动凝血仪对260例临产孕妇和260例健康育龄期非妊娠妇女（对照组）进行红细胞参数以及凝血四项指标的检测.结果 与对照组比较临产孕妇组的红细胞、血细胞压积、血红蛋白、平均红细胞体积、平均红细胞血红蛋白量、平均红细胞血红蛋白浓度均比正常对照组减低而红细胞体积分布宽度RDW则高于对照组,两者之间均有显著性差异（P〈0.01）.临产孕妇组的血浆凝血酶原时间、活化部分凝血活酶时间、凝血酶时间均缩短而纤维蛋白原含量则增高,两组间比较有显著性差异（P〈0.01）.结论 临产孕妇多伴有不同程度的贫血且以小细胞低色素性贫血为主;临产孕妇血液呈高凝状态容易引起妊娠期高血压疾病以及弥散性血管内凝血.

Objective To investigate changes and clinical significance of erythrocyte parameters and blood coagulation 4 indices of parturient women. Methods Red blood cell parameters and blood coagulation indices of 260 parturient women （parturient women group） and other 260 non-pregnant women （ control group ） were detected with Mindry BC-3000Plus automatic blood cell analyzer and Sysmex CAS00 automatic blood coagulation analyzer. Results Compared with the control group, red blood cell count （RBC） , hemotoerit （HCT）, hemoglobin （Hb）, mean corpuscular volume （MCV）, mean corpuscular hemoglobin （MCH） and mean corpuscular hemoglobin concentration （MCHC） of the parturient women in the parturient women group were decreased significantly （all P 〈0.01 ）, while red blood cell volume distribution width （RDW） was increased significantly （ P 〈 0.01 ）. The prothrombin time （ PT）, activated partial thomboplastin time （APTF） and thrombin time （TT） of the parturient women were shorter but content of fibfinogen （FIB） was increased and there were significant differences between the two groups （ all P 〈 0.01 ）. Conclusion Parturient women mostly suffer from varied degrees of anemia and microeytic hypochromic anemia is the major type. Hypercoagnlabale state could occur in parturient women which were liable to induce hypertensive disorder complicating pregnancy （HDCP） and disseminated intravascular coagulation （DIC）.