摘要
目的:建立牛黄上清微丸制备方法。方法:以收率和圆整度优选挤出滚圆法制备工艺。结果:牛黄上清提取物加等量微晶纤维素,混匀,加30%水做黏合剂制软材,选择孔径为1.0 mm的筛板,挤出速度为30 r·min-1,滚圆速度50 Hz,滚圆时间为6 min。结论:微丸外表美观,质量稳定。
Objective： To establish a preparation method of Niuhuang Shangqing pellets. Method： Optimization of yield and roundness was prepared by extrusion-spheronization process and researched the dissolution of pellets in vitro. Result ： Blend the extraction with MCC, and add adequate water. Squeeze with 30 r. min^-1 and roll 6 rain with the rate 50 Hz, drying and screening. Conclusion： The pellets had a good appearance and stable quality.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第17期10-11,14,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
"重大新药创制"科技重大专项(2009ZX09301-005)
关键词
牛黄上清微丸
制备工艺
挤出-滚圆法
Niuhuang Shangqing pellets
preparation
extrusion-spheronization
