中心组合设计法优化黄连解毒黏附微球处方工艺

Optimization of Formulation of Huanglian-jiedu Bioadhesive Microspheres by Central Composite Design

目的:确定黄连解毒黏附微球的最佳处方工艺。方法:以成品收率,小檗碱、栀子苷、黄芩苷包封率,微球在人工胃液中的黏度为指标,采用中心组合设计法优化黄连解毒黏附微球的处方工艺,对结果进行二项式拟合,对最优条件进行预测分析。结果:各指标二项式方程拟合度较好,按处方优化得到最佳条件制备黄连解毒黏附微球,各项指标与预测值接近。结论:中心组合设计法优化黏附微球工艺条件准确、可靠。

Objective：To optimize the formulation of Huanglian-jiedu bioadhesive microspheres. Method： The optimum formulation was investigated by central composite design with five responses ie. yield, entrapment efficiency of three effective ingredients and mucoadhesive property. The data were imitated using second-order polynomial equation, and the numerical optimization was performed. Result： Prepare microspheres with optimum formulation, and the responses approached the prediction at the optimum. Conclusion： The performulation and preparation of microspheres were reasonable and reliable.