人参藏红花组合物预防急性高原反应的研究

Study on Combination of Ginseng and Saffron for Prevention of Acute Mountain Sickness

目的:研究人参藏红花组合物预防急性高原反应的作用。方法:将昆明小鼠按照体重随机分为5组,分别为空白组、诺迪康0.56 g·kg-1组、人参藏红花组合物20,10,5 g·kg-1组。预先给予小鼠人参藏红花组合物7 d,末次给药后1 h观察其在常压缺氧环境下的存活时间,低压低氧后的游泳时间以及在低压低氧环境下的死亡率。结果:人参藏红花组合物20,10,5 g·kg-1均能延长常压缺氧小鼠的存活时间及低压低氧后小鼠的游泳时间,但对低压低氧环境下小鼠的死亡率无影响。结论:人参藏红花组合物能够提高小鼠的耐缺氧和抗疲劳能力,可用于预防急性高原反应。

Objective： To study the preventive effects of the combination of ginseng and saffron for acute mountain sickness.Method： Kunming mice were randomized into 5 groups（control,Nuodikang 0.56 g.kg-1,the combination of ginseng and saffron 20,10,5 g·kg-1）.The combination of ginseng and saffron was administered to mice once daily for 7 days.One hour after the last medication,the survival time was observed in mice using normobaric hypoxia.The time of swimming and the death rate were investigated in mice using hypobaric hypoxia.Result： The combination of ginseng and saffron（20,10,5 g·kg-1） prolonged the survival time in mice under normobaric hypoxia and the swimming time in mice under hypobaric hypoxia,but had no significant effect on the death rate in mice with hypobaric hypoxia.Conclusion： The combination of ginseng and saffron has anti-hypoxia capacity in mice and can be used to prevent acute mountain sickness induced by environmental hypoxia.