跌打消痛片的祛瘀、抗炎作用研究

Effects of Dieda Xiaotong Tablet on Removing Blood Stasis and Anti-inflammation

目的:通过对跌打消痛片祛瘀、抗炎作用的药理研究,为临床应用提供试验依据。方法:将大鼠、豚鼠和小鼠随机分为模型、阳性对照和跌打消肿片低、中、高剂量组,用打击法和钳夹法造成瘀血模型,ig给予跌打消肿片7d,测量蓝斑面积、吸光度A和瘀斑消退面积;用二甲苯及棉球肉芽肿造成炎症模型,测定鼠耳肿胀度和大鼠肉芽重。结果:跌打消痛片能显著降低外伤瘀血型大鼠的受伤腿部皮肤蓝斑面积和依文思蓝含量;能显著降低豚鼠局部皮肤创伤性瘀斑消散率(P<0.01);对二甲苯引起的鼠耳肿胀和大鼠棉球肉芽肿等,均有明显抑制作用(P<0.01)。结论:跌打消痛片有明显的祛瘀、抗炎作用。

Objective： To study the effects of removing blood stasis and anti-inflammatory of Dieda Xiaotong Tablet to provide an experimental foundation for clinical application.Method：The removing blood stasis effect was demonstrated with rat and guinea pig models of hemostasis induced by local punching and clamping accordingly.The anti-inflammatory effect was determined with the models of the swelling ear in mice and cotton ball induced granuloma in rat.The treatment（ig） of Dieda Xiaotong Tablet lasted for 7 days.Result：Dieda Xiaotong Tablet markedly reduced blue stain area of skin and Evans content of in hemostasis rats.It could also suppress ear swelling caused by dimethylbenzene in mice and cotton ball induced granuloma in rat（P 0.01）.Conclusion： Dieda Xiaotong Tablet possesses obvious effect of removing blood stasis and anti-inflammatoion.