中药结合针刺治疗对椎-基底动脉供血不足患者血管内皮功能的影响

Effect of Acupuncture Combined with Oral Traditional Chinese Medicine on Levels of Vascular Endothelial Function in Patients with Vertebro-Basilar Insufficiency

目的:观察针药结合治疗对椎-基底动脉供血不足患者椎-基底动脉血流速、血管内皮功能的影响。方法:98例椎-基底动脉供血不足患者随机分为针药组(口服自拟化痰定眩汤联合针刺)和西药组(口服盐酸氟桂利嗪胶囊),动态监测治疗前后椎-基底动脉血流速、血清一氧化氮(NO)、血浆内皮素-1(ET-1)、血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)的水平变化。结果:与治疗前比较,治疗后2组患者椎-基底动脉血流速均显著改善(P<0.05),血清(浆)NO,6-keto-PGF1α水平升高,ET-1,TXB2水平降低(P<0.05);针药组改善椎-基底动脉血流速优于西药组(P<0.05);针药组改善椎-基底动脉血流速、升高血清NO与6-keto-PGF1α的含量水平、降低血浆TXB2含量的作用均明显优于西药组(P<0.05)。结论:针药结合治疗可显著改善患者椎-基底动脉血流速及血管内皮功能,提高治愈好转率。

Objective：To observe the effect of a acupuncture medication combined regimen（AMCR） on the vascular endothelial function and the velocity of blood flow in the vertebral-basilar artery in patients with vertebro-basilar insufficiency（VBI）.Method： Adopting randomized and controlled principle,a trial was conducted on 98 patients with VBI by randomized them into two groups,they were administered AMCR（Group A） and flunarizine hydrochloride capsule（Group B）respectively,for 20 days.Changes of the velocity of blood flow in the vertebral-basilar artery,as well as the levels of serum nitric oxide（NO）,plasma endothelin-1（ET-1）,6-keto-prostaglandin1α（6-keto-PGF1α） and thromboxane B2（TXB2） were observed before and after treatment.Result：After treatment the velocity of blood flow in the vertebral-basilar artery increased and clinical symptoms improved,with serum NO and 6-keto-PGF1α levels elevated,plasma ET-1 and TXB2 decreased in all the two groups（P 0.05）.But the intergroup comparisons showed that the effect in Group A was superior to the other group in increasing the velocity of blood flow in the vertebral-basilar artery,elevating serum NO and 6-keto-PGF1α levels and decreasing plasma TXB2（P 0.05）.Conclusion： The AMCR has markedly effect in increasing the velocity of blood flow in the vertebralbasilar artery,it could obviously improve the symptoms and vascular endothelial function,and inhibit the level ofinflammatory factor in patients with VBI.