铁负荷过载研究进展及治疗

Iron overload:advances in research and treatment

铁是人体必需营养元素,广泛参与机体生理功能和生化反应。当体内铁过多时则称为铁负荷过载。随着医疗条件改善、生活水平提高,源于生理性因素、病理性因素和外源性铁剂应用(治疗性应用、预防性应用),铁负荷过载相关疾病日益增多。铁过载可对内分泌代谢、心血管、神经系统、肝脏等系统器官产生损害,导致多种疾病或使疾病加重。本文就铁负荷过载的病因、发病机制、组织损伤及治疗研究进展做一综述。

Iron is an essential nutrition element of human body and participates in a wide range of physiological functions and biochemical procedures.Along with the improving medical services and better living standard,excessive supply of iron in the body that arise from psychological or pathological factors or use of iron supplements（for therapeutic or preventive purposes）,known as iron overload,has been increasingly linked to a variety of diseases.Iron overload can be harmful to endocrinal metabolism,cardiovascular system,nervous system,liver and other organs in the body,and may induce or deteriorate a number of diseases.Updates in etiology,pathogenesis,tissue injury and treatment of iron overload were reviewed in this paper.