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儿童慢性乙型肝炎抗病毒治疗的时机与方案选择 被引量:11

The trealment options of antiviral therapy for chronic hepatitis B in children
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摘要 儿童慢性乙型肝炎(CHB)可进展至严重的肝脏损害,包括肝硬化、肝衰竭,甚至肝癌。亚太大部分地区,尤其在我国90%以上的成人CHB源于儿童期感染。因此儿童CHB的抗病毒治疗越来越受到关注,有效的抗病毒治疗能够阻止肝脏疾病的活动性进展,从而降低成人活动进展型肝病和晚期重症肝病的发生率。
作者 张鸿飞
机构地区 北京解放军
出处 《中国实用儿科杂志》 CSCD 北大核心 2010年第12期903-905,共3页 Chinese Journal of Practical Pediatrics
关键词 儿童 慢性乙型肝炎 抗病毒治疗 children chronic hepatitis B antiviral therapy
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参考文献14

  • 1张鸿飞,朱世殊,杨晓晋,徐志强,董漪,陈大为,赵景民,陈菊梅,张太和.小儿乙、丙型肝炎临床与病理研究[J].传染病信息,2006,19(3):130-131. 被引量:24
  • 2Chang MH, Chen TH, Hsu HM, et al. Prevention of hepatocellular carcinoma by universal vac-cination against hepatitis B virus: the effect and problems[J]. Clin Cancer Res, 2005,11 : 7953-7957.
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  • 4张鸿飞.小儿乙型肝炎干扰素治疗的有关问题[J].中华肝脏病杂志,2002,10(2):140-140. 被引量:12
  • 5Zhu SS, Zhang HF, Dong Yi, et al. Evaluation of safety and efficacy of extended pegainterferon-α-2a therapy in children with HBeAg-positive chronic hepatilis B [C]. APASL, 2010: 251.
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  • 7Sokal EM, Kelly DA, Mizerski J, et al. Long-term lamivudine treatment in children with HBeAg-positive chronic hepatitis B [J ]. Hepatology, 2006,43 : 225-232.
  • 8Akman SA, Kose S, Halicioglu O. Lamivudine and adefnvir resistance in children and young adults with chronic hepatitis B [J]. Int J Infect Dis,2010, 14(3) :236-239.
  • 9Jonas MM, Kelly D, Pollack H, etal. Safety, efficacy, and pharmacokinetics of adefovir dipivoxil in children and adoleseents (age 2 to < 18 years)with chronic hepatitis B [J]. Hepatology.2008,47(6) : 1863-1871.
  • 10Kansu A, Doganei T, Akman SA, et al. Comparison of two different regimens of combined intefferon-alpha2a and lamivudine therapy in children with ehronie hepatitis B infeetian[J]. Antivir Ther, 2006,11 : 255-261.

二级参考文献5

  • 1Guido M , Bortolotti F, Rugge M . Is liver biopsy needed in children with chronic hepatitis [J] . Acta Gastroenterol Belg,1998,61 ( 2 ) : 214-216.
  • 2Steindl P, Ferenci P, Dienes HP, et al. Wilson's disease in patients presenting with liver disease: a diagnostic challenge[J]. Gastroenterology, 1997, 113 ( 1 ):212-218.
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  • 4中华医学会传染病与,寄生虫病学分会,肝病学分会.病毒性肝炎防治方案[J].中华肝脏病杂志,2000,8(6):324-329. 被引量:14009
  • 5张鸿飞,杨晓晋,朱世殊,赵景民,张太和,徐志强,陈大为,王松山,陈菊梅.1020例小儿肝穿刺组织病理学与临床的研究[J].中华儿科杂志,2002,40(3):131-134. 被引量:25

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