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轻度胃肠炎伴良性婴幼儿惊厥30例脑脊液中神经元特异性烯醇化酶检测分析 被引量:17

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摘要 目的研究轻度胃肠炎伴良性婴幼儿惊厥(BICE)患儿中枢神经元的损伤情况。方法以2007年10月至2010年3月中国医科大学深圳儿童医院癫痫中心住院的30例BICE为观察组,并根据患儿入院前惊厥发作次数分为惊厥>2次组和惊厥≤2次组,选择同期脊膜膨出14例患儿为阴性对照组。应用酶联免疫吸附技术(ELISA)检测两组患儿脑脊液中神经元特异性烯醇化酶(NSE)。结果观察组NSE高于阴性对照组(P<0.05);惊厥>2次组与惊厥≤2次组及阴性对照组之间比较NSE差异有统计学意义(P<0.05);惊厥>2次组NSE质量浓度高于阴性对照组(P<0.05),而惊厥≤2次组与阴性对照组之间比较NSE差异无统计学意义(P>0.05)。结论 BICE在惊厥频繁发作时对中枢神经元会造成损伤,惊厥发作不频繁时则对神经元的损伤不明显。
出处 《中国实用儿科杂志》 CSCD 北大核心 2010年第12期948-949,共2页 Chinese Journal of Practical Pediatrics
基金 深圳市医学重点学科建设资助(2001B20)
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