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IGF-1/IGFBP-1与妊娠期疾病的相关性研究现状 被引量：11

Research Progress in the Relationship between IGF-1/IGFBP-1 and Diseases in Pregnancy
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摘要 近年,胰岛素样生长因子1(IGF-1)及其结合蛋白1(IGFBP-1)在产科领域中的作用与应用逐渐被认识。IGF-1是一种重要的组织生长因子,具有类胰岛素及促有丝分裂作用。IGFBP-1作为一种内分泌因子,在妊娠的不同时期,通过其含量和磷酸化程度的变化来调节IGF-1,与妊娠高血压疾病、妊娠期糖尿病、胎儿生长发育异常等妊娠期疾病以及胎膜早破、预测早产密切相关。 In recent years,the roles and application of insulin-like growth factor-1（IGF-1） and its binding protein-1（IGFBP-1） in the field of obstetrics has been gradually recognized.IGF-1 is an important tissue growth factor that has an insulin-like and mitogenic effect.IGFBP-1,as an endocrine factor,in different periods of pregnancy,through its content and extent of phosphorylation to regulate IGF-1.It is closely associated with gestational hypertension,gestational diabetes,abnormal fetal growth,and gestational diseases,such as premature rupture of membrane and preterm labor.
作者 金爽 尹春艳
机构地区 南华大学教学医院 广东省第二人民医院
出处 《医学综述》 2010年第23期3553-3555,共3页 Medical Recapitulate
关键词 胰岛素样生长因子1 胰岛素样生长因子结合蛋白1 妊娠期疾病 诊断 Insulin-like growth factor-1 Insulin-like growth factor binding protein-1 Gestational diseases Diagnosis
分类号 R714 [医药卫生—妇产科学]
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参考文献22

  • 1Altinkaynak K,Aksoy H,Bakan E,et al.Serum IGF-1and IGFBP-3 in healthy pregnancies and patients with preedampsia[J].Clin Biochem,2003,36(3):221-223.
  • 2Ozkan S,Vural B,Filiz S,et al.Placental expression of insulin-like growth factor-I,fibroblast growth factor-basic,and neural cell adhesion molecule in preeclampsia[J].J Matern Fetal Neonatal Med,2008,21(11):831-838.
  • 3Ninq Y,Williams MA,Vadachkoria S,et al.Maternai plasma concentrations of insulin-like growth factor-1 and insulin-like growth factor-binding protein-1 in early pregnancy and subsequent risk of preeclampsia[J].Clin Biochem,2004,37(11):968-973.
  • 4Vatten LJ,Nilsen TI,Juul A,et al.Changes in circulating level of IGF-1 and IGF-binding protein-1 from the first to second trimester as predictors of preeclampsia.Eur[J].Endocrinol,2008,158(1):101-105.
  • 5Hietala R,Pohja-Nylander-P,Rutanen EM,et al.Serum insulin-like growth factor binding protein-1 at 16 weeks and preeclampsia[J].Obstet Gynecol,2000,95(2):185-189.
  • 6Hubinette A,Lichtenstein P,Brismar K,et al.Serum insulin-like growth factors in normal pregnancy and in pregnancies complicated by preeclampsia[J].Acta Obstet Gynecol Scand,2003,82(11):1004-1009.
  • 7Lindsay RS,Westqate JA,Beattie J,et al.Inverse changes in fetal insulin-like growth(IGF)-1and IGF binding protein-1 in association with higher birth weight in maternal diabetes[J].Clin Endocrinol(Oxf),2007,66(3):322-328.
  • 8Loukovaara M,Leinonen P.Effect of maternal diabetes on phosphorylation of insulin-like growth factor binding protein-1 in cord serum[J].Diabet Med,2005,22(4):434-439.
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  • 10Setia S,Sridhar MG.Changes in GH/IGF-1 axis in intrauterine growth retardation:consequences of fetal programming[J].Horm Metab Res,2009,41(11):791-798.

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医学综述
2010年 第23期

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