乙型肝炎病毒基因型别及X基因变异的研究进展

Research Progress of Hepatitis B Virus Genotypes and X Gene Mutation

乙型肝炎病毒是一个以RNA为中间体的反转录复制病毒,由于RNA聚合酶缺乏校正功能,这使其突变率明显高于一般的DNA病毒,随着分子生物学研究技术的进展,不断有新的HBV基因型和亚型被发现。对和疾病进程、治疗相关的HBV基因型和X基因变异进行研究,有助于对疾病的控制和治疗提供更好的理论依据,在控制HBV感染上具有重要的意义。

Hepatitis B virus（HBV） is a reverse transcription RNA virus,Due to the fact that RNA polymerase is unable to proof the reverse transcription,HBV has a high incidence of mutation in contrast to other DNA viruses.The advancement in molecular technology has been identifying more HBV genotypes and subtypes.The investigation into HBV genotypes and X gene mutation associated with progress and treatment of HBV is helpful for the control and treatment of HBV,especially in term of controlling HBV infection.