摘要
一些趋化因子在急性胰腺炎相关性肺损伤(APALI)的发病和发展中所起的作用越来越受到重视,如白细胞介素8、单核细胞趋化蛋白1、生长相关原癌基因、正常T细胞表达和分泌的活化调节蛋白等。多种趋化因子的高表达可能是APALI的原因之一,应用趋化因子受体拮抗剂可明显改善APALI。对趋化因子及其受体的深入研究能给APALI的治疗提供新的策略。
Some researches confirmed that some chemokines are important in the pathogenesis of acute pancreatitis-associated lung injury,such as IL-8、MCP-1、GRO、RANTES and etc.Several studies have reported that high-expression of some chemokines may be one of factors in acute pancreatitis-associated lung injury,application of chemokine antagonist can significantly improve acute pancreatitis-associated lung injury.The deep research on the chemokine and their receptors,will provide new strategy for the therapy of acute pancreatitis-associated lung injury.
出处
《医学综述》
2010年第23期3574-3576,共3页
Medical Recapitulate
