树突状细胞与肠道免疫屏障

Dendritic Cells and Gut Immune Barrier

肠相关淋巴组织在防御病毒、细菌、寄生虫等有害侵袭的过程中发挥着重要的屏障作用,其中肠道树突状细胞最为关键。作为最强有力的专职抗原递呈细胞,树突状细胞能够摄取、加工肠道微生物抗原和其他口服抗原,呈递给T细胞、B细胞、自然杀伤细胞等效应淋巴细胞并使之致敏,通过这些致敏淋巴细胞及其合成的特异性抗体、细胞因子清除有害的病原微生物,同时对肠道正常菌群以及口服抗原保持免疫耐受。

Gut-associated lymphoid tissue（GALT）play a key role in process of gut defense against viruses,bacteria,parasites,etc,especially dendritic cells in gut.As the most powerful and professional antigen presenting cells,DCs can capture,process microbial antigens and oral antigens,present these antigens to T cells,B cells,NK cells and other effector cells,and activate them.All of these activated cells and their special antibodies,cytokines can clear the harmful pathogenic microorganisms,or maintain tolerance to normal intestinal flora and oral antigen.