血管炎性反应与高血压的研究进展

Progress in Vascular Inflammation and Hypertension

慢性炎性反应与血管性疾病的发生、发展密切相关。但作为血管性疾病的高血压,其发病机制复杂且至今仍不清楚。早期的动物实验结果显示,高血压动物血管壁以及血浆中的炎性因子水平均升高。流行病学和临床试验表明,高血压患者血浆炎性因子水平显著高于血压正常人群。大规模临床药物干预研究证明,一些降压药物在降压的同时,能显著降低患者血浆中若干种炎性因子的水平。在此分析基础动物实验、流行病学调查和大规模临床干预结果与炎性因子相关性,期望能为将来相关临床研究和药物干预提供新的思路。

Chronic inflammation has been reported to be related to the development of vascular disease.Hypertension is a vascular disease and its pathogenic mechanism is complicated and still unknown.Early hypertensive animal experiments showed that the levels of inflammatory factors increased both in vascular wall and blood stream in animal models.Lately,both epidemic research and clinical trials on hypertension have proved that the levels of inflammatory factors in the hypertensive are higher than those in the non-hypertensives.Furthermore,drug interventional research results demonstrated that antihypertensive drugs（not all）could decrease significantly the levels of some plasma inflammatory factors,besides their anti-hypertensive effects.A correlation analysis was made amomg basical experiements,epedemilogical investigations,large scales of clinical intervention results and inflammation factors,which is antincipated to provide a new idea for some relevant clinic studies and medical intervention experiments.