脑白质病变与轻度认知功能障碍的研究进展

Study of White Matter Lesions and Mild Cognitive Impairment

随着人类平均寿命的延长、人口的老龄化,老年人认知功能障碍逐年增多,轻度认知功能障碍作为阿尔茨海默病(AD)的危险因素及AD的前期表现,对于AD的早期诊断早期治疗具有重要的临床意义,已越来越受到人们的关注。研究显示,脑白质病变作为老年人常见的脑部损害并被认为是脑缺血的重要标志,可引起大脑高级神经功能障碍,与认知功能障碍及AD的发生、发展密切相关。现就近年来脑白质病变与认知功能障碍的相关研究予以综述。

With the extension of the human life expectancy,there are more and more cognitive impairment occurring in the elderly population.Mild cognitive impairment is considered as the prophase of the Alzheimer′s disease（AD）,which is clinically significant for the diagnosis and treatment of AD,as an increasing concern.Studies show that white matter lesion,as the frequent brain injury of and the symbol of cerebral ischemia,is closely associated with the cognitive impairment and AD.In this paper,the association between white matter lesion and mild cognitive impairment in recent years were reviewed.