心房颤动药物治疗的新靶点

New Targets of Pharmacological Therapy for Atrial Fibrillation

心房颤动(AF)的药物治疗仍是基本的治疗方式。最近提出了一些新的药物作用靶点,例如心房选择性离子通道,其阻滞剂可以转复AF和维持窦性心律,且没有严重室性心律失常的风险。缝隙连接是又一新的作用靶点,其解耦联可以导致复极的不均一性,使部分缝隙连接开放可以抑制AF。心房离子通道、结构和电生理的重塑与AF的发生和维持有关,因此,抑制心房重塑可以延缓AF的发生。

The medical treatment of atrial fibrillation（AF）remains as the basic rhythm management.Recently,several targets of AF treatment have emerged,such as atria-selective iron channels and blocking agents,which restore and maintain the sinal rhythm in AF patients without increasing the risk of severe ventricular arrhythmia.Gap junction is another new target of AF treatment and its uncoupling can cause the heterogeneities of repolarization.Enhancing the conduction through reopening the partially closed gap junctions can prevent AF.The ionic,structural and electrophysiological atrial remodeling contribute to the occurrence and maintenance of AF.Hence,an effective modality to delay or prevent these remodeling will potentially retard the progression of AF.