老年下呼吸道感染患者铜绿假单胞菌耐药性分析

目的分析老年下呼吸道感染住院患者的铜绿假单胞菌对抗生素的耐药性,为指导临床合理用药提供可靠依据。方法对2008年5月～至2010年5月入院治疗的老年下呼吸道感染患者173例,进行细菌鉴定及药敏试验,分析抗生素的使用情况及耐药性。结果全部患者在铜绿假单胞菌检出前2周内均使用过多种抗生素,其中青霉素类68例,头孢类86例,喹诺酮类34例,氨基糖苷类20例;铜绿假单胞菌耐药现象较为严重,其中以氨苄西林最高,占88.44%,依次为头孢唑啉(82.65%)、头孢曲松(67.63%)。结论铜绿假单胞菌对多种常用抗生素素耐药严重,存在多重耐药性,临床用药时应根据药敏试验合理选择抗生素。

Objective To analyze the prevalence of drug resistance Pseudomonas aeruginosa infection of lower respiratory tract bacterial infection of the old patients,in order to provide reliable evidence for clinic drug use. Methods 173 cases were identif ied ,antimicrobial susceptibility tests were performed. The utilization of antibiotics and drug resistant were analyzed during May 2008 to May 2010. Results All patients used many kinds of antibiotic before cultivate the Pseudomonas aeruginosa.68 cases were given penicillin,86 cases were given cephalosporins,34 cases were received quinolones,20 cases were received aminoglycoside. The result of resistance analysis showed Pseudomonas aeruginosa are multiplex resistant. The resistant rate to ampicillin was 88.44%,the next were cefazolin（82.65%） and ceftriaxone（67.63%）.Conclusion Pseudomonas aeruginosa is highly resistant to common antimicrobials and demonstrate multi-drug resistance. For old patients with lower respiratory tract bacterial infection ,antibiotics should be reasonably selected based otn the result of drug sensitivity test.