慢性心力衰竭患者血清尿酸水平变化及临床意义

目的探讨慢性心力衰竭(CHF)患者血清血尿酸水平的变化及临床意义。方法将2008年5月至2010年2月收治的CHF患者79例按心功能分级与不同病因分组,并与健康对照组的血清血尿酸水平相比较。结果按心功能分级组比较血清尿酸水平差异显著(P<0.O1);不同病因所致CHF患者血尿酸水平均升高(P<0.05),CHF纠正后血尿酸水平显著降低较治疗前有明显差异(P<0.01)。结论心衰越严重血尿酸浓度越高,心功能改善后血清尿酸浓度明显下降,动态检测血清尿酸浓度是判断CHF的治疗效果的一个有意义的生化指标。

Objective To investigate the chronic heart failure （CHF） level of serum uric acid changes and clinical significance. Methods May 2008 to February 2010 79 patients were treated according to CHF NYHA classifi cation groups with different causes,and with the healthy control group compared with the serum uric acid levels. Results According to NYHA classif ication group differences in serum uric acid levels were significantly （P〈001）; different causes acidic urine in patients with chronic heart failure increased by an average （P〈0.05）,heart failure corrected significantly lower serum uric acid level significant difference compared with before treatment （P〈0.01）. Conclusion The more severe heart failure,higher serum uric acid concentrations,heart function improved significantly decreased serum uric acid levels,dynamic testing is to determine serum uric acid in the treatment of heart failure,a significant chemical and biological indicator.