非小细胞肺癌血管内皮生长因子表达的临床意义

目的探究非小细胞肺癌患者血清VEGF水平的临床意义。方法用酶联免疫吸附试验(ELISA)方法检测35例非小细胞肺癌患者和随机选择的30例健康成年人的VEGF水平,分析评估其在非小细胞肺癌诊断中的应用价值。结果非小细胞肺癌组的VEGF水平(16.11±2.21)μg/L)显著高于正常成年组(10.481±2.02)μg/L)(P<0.05)。非小细胞肺癌病人患者的VEGF水平随着TMN分期的进展逐渐升高,有淋巴结转移者高于没有淋巴结转移者(P<0.01),低分化肿瘤高于中等和高分化肿瘤(P<0.05)。结论血清VEGF水平可作为非小细胞肺癌病人患者的诊断和临床进展的评价指标。

Objective To investigate the clinic significance of serum vascular endothelial growth factor （VEGF） levels in the patients with nonsmall-cell-lung-cancer （NSCLC）. Methods The serum VEGF levels in 35 in patients with NSCLC and randomly selected 30 healthy subjects were assayed by ELISA. And its significance of diagnostic and prognosis in the NSCLC then are were analyzed. Results VEGF of NSCLC patients group was signifi cantly high （16.11±2.21）μg /L than that of normal healthy subjects（10.481±2.02）μg /L,P〈0.05. Furthermore,the serum level of VEGF is related with the progression of TMN staging,and lymph node positive patients were higher then lymph node negativesP〈0.01and low differentiate tumors were higher than intermediate and highly differentiated tumors P〈0.05. Conclusion The results suggest that serum VEGF level is useful maker for diagnosis and prognosis of NSCLC.