肌内黏液瘤临床病理特点研究

Clinicopathological characteristics of intramuscular myxoma

目的:研究肌内黏液瘤的临床病理学特点,探讨其诊断和鉴别诊断。方法:对2例肌内粘液瘤进行临床病理分析,并应用VIM、CD34、SMA、S-100进行免疫组化染色。结果:肿瘤有粘滑外观,镜下见肿瘤由丰富的粘液样基质及稀少的星芒状、短梭形细胞构成,血管结构稀少,部分区域可见浸润周围骨骼肌;免疫组化Vim(2例均阳性),CD34(其中1例阳性),S-100、SMA均为阴性。结论:肌内黏液瘤是少见的来源不明的良性软组织肿瘤,可以根据形态学和免疫组化加以诊断,需与一些肿瘤做鉴别诊断;完整切除,预后良好。

ObjectiveTo study the clinicopathological features of intramuscular myxoma and to explore the diagnosis and differential diagnosis of it.MethodTwo cases of intramuscular myxoma were analyzed by histological observation and immunohistochemical staining of VIM,CD34,SMA,S-100.ResultsThe tumor has a mucoid,gelatinous cut surface with thin fibrous septa.On histologic examination the tumor was composed of abundant mucoid material and a paucity of stellate-shaped and short spindle cells,with sparse vascular structures.Infiltration of the surrounding skeletal muscle can be seen in some areas.Immunohistochemically,the tumor cells were positive for vimentin in both cases,and positive for CD34 in one case.Both cases did not stain for S-100 or SMA.ConclusionIntramuscular myxoma is a rare uncertain benign soft tissue tumor.Appropriate diagnosis can be received according to its histopathologic and immunohistochemical features,and differential diagnosis should be made from some other myxoid neoplasms.Patients with intramuscular myxoma might obtain favorite outcome after complete excision.