以斑马鱼为模式生物的辐射效应修饰剂研究

Study on radiation modifiers with zebrafish as a vertebrate model

利用斑马鱼作为模式生物,进行一系列的实验研究,尤其在胚胎发育、基因表达、药物筛选和疾病模型方面有其独特的优势。但它被应用于辐射效应修饰剂的研究时间较短,已有的文献显示发展前景良好。本工作就近些年以斑马鱼为模式生物研究的辐射效应修饰剂进行概述,主要涉及如氨磷汀、DF-1、AG1478、Flavopiridol和一些DNA损伤修复蛋白。

Zebrafish（Danio rerio） as a vertebrate model system has been used in a series of biomedical experiments by scientists.It offers distinctive benefits as a laboratory model system,especially for embryonic development,gene expression,drug screening and human disease model.In this paper,the typical radiation modifiers,such as Amifostine,DF-1,AG1478,Flavopiridol and DNA repair proteins involved in biomedical process by use of zebrafish have been reviewed.