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HIV感染患者外周血T淋巴细胞CD127表达的研究进展

Research progress of CD127 expression on T lymphocytes in peripheral blood with HIV infection
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摘要 白细胞介素7受体（IL-7R）是由α链及γ链构成的,γ链受体广泛表达于淋巴细胞,是IL-2、IL-4、IL-9、IL-15和IL-21的通用受体,可以与这些细胞因子结合并相互作用.CD127是IL-7Rα链,在T淋巴细胞发育过程中,胸腺细胞的分化依赖于IL-7的表达.IL-7可以通过CD127刺激外周非同种异基因反应性T淋巴细胞的增殖,并通过抗凋亡作用促进T淋巴细胞的存活与重构,维持T淋巴细胞内环境稳态[1].
作者 陈亚宝 叶军
机构地区 江苏省泰州市人民医院临床医学检验中心
出处 《中华临床感染病杂志》 CAS 2010年第4期251-253,共3页 Chinese Journal of Clinical Infectious Diseases
关键词 白细胞介素7受体α亚单位 T淋巴细胞 HIV感染 Interleukin-7 receptor alpha submit Tlymphocyte HIV infection
分类号 R51 [医药卫生—内科学]
  • 相关文献

参考文献17

  • 1Alpdogan O,Muriglan SJ,Eng JM,et al.IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation.J Clin Invest,2003,112(7):1095-1107.
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二级参考文献13

  • 1Zaunders J J, Ip S, Munier ML, et al. Infection of CD 127+(interleukin- 7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T celLs during primary human immunodeficiency virus type 1 infection. J Virol, 2006, 80: 10162- 10172.
  • 2Paiardini M, Cervasi B, Albrecht H, et al. Loss of CD127 expression defines an expansion of efector CD8+ T cells in HIV-infected individuals. J Immunol, 2005, 174: 2900-2909.
  • 3Failer E, Kakal J, Kumar R, et al. IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells. Int Immunol, 2009, 21: 203-216.
  • 4Lang KS, Recher M, Navarini AA, et al. Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation. Eur J Immunol, 2005, 35: 738-745.
  • 5Boettler T, Panther E, Bengsch B, et al. Expression of the interleukin- 7 receptor alpha chain (CD 127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection. J Virol, 2006, 80: 3532-3540.
  • 6Lopes AR, Kellam P, Das A, et al. Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection. J Clin Invest, 2008, 118: 1835-1845.
  • 7Alpdogan O, Muriglan S J, Eng JM, et al. IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. J Clin Invest, 2003, 112: 1095-1107.
  • 8Li J, Huston G, Swain SL. IL-7 promotes the tmansition of CD4 effectors to persistent memory cells. J Exp Med, 2003, 198:1807- 1815.
  • 9Kondraek RM, Harbertson J, Tan JT, et al. Interleukin 7 regulates the survival and generation of memory CD4 cells. J Exp Med, 2003, 198: 1797-1806.
  • 10Kaech SM, Tan JT, Wherry EJ, et al. Selective expression of the interhukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol, 2003, 4:1191-1198.

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中华临床感染病杂志
2010年 第4期

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